Pathogenesis of Jeilongvirus

https://reporter.nih.gov/search/55EboCAy20ia8Cf86FMn5w/project-details/9700578

J paramyxovirus (JPV) was first isolated from rodents in the early 1970s in Australia. Its genome structure was determined In 2005. 
 In 2006, Beilong virus (BeiPV) was isolated from human kidney mesangial cells (HMCs) as a contaminant from a rat cell line. BeiPV has the same genome structure as JPV. Studies indicate that BeiPV is a rodent virus. Because of their unique genome structure, a new genus, Jeilongvirus, was proposed to classify JPV and BeiPV within the paramyxovirus family. Tailam virus (TlmPV), isolated from the kidney of a Sikkim rat in Hong Kong in 2011, has an identical genome structure as JPV and BeiPV, indicating that it is a member of Jeilongvirus genus. In 2014, a likely member of Jeilongvirus genus was identified from the primary culture of grey squirrel kidney cells from the UK. In addition, RNA sequences of JPV-like viruses have been identified in rodents and bats in Africa, Europe, and China (personal communication) since 2012, indicating that Jeilongvirus is widely distributed and infects a variety of mammals. At present, very little is known about this new and emerging class of viruses. 
The researchers have chosen JPV as a prototype of Jeilongvirus, because they have identified a strain of JPV that is pathogenic in laboratory mice. The researchers have established an animal model for in vivo pathogenesis studies and a reverse genetics system for manipulating the RNA genome of JPV.